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Cytogenetics
As an increasing number of
chromosomal abnormalities have been found to be associated with
specific hematologic malignancies and disorders, cytogenetic
analysis has become a cornerstone in the diagnosis and
prognosis of acute and chronic leukemias, lymphomas and
multiple myeloma, as well as offering insights into potential
therapeutic response.
Genoptix offers traditional
G-banding, as well as other identification techniques, in
support of COMPASS Evaluation for Blood and Bone Marrow, which
also includes morphology, flow cytometry and PCR findings.
Molecular Cytogenetics
Fluorescence in situ hybridization (FISH) can provide a number
of advantages over classic cytogenetics in the detection of
chromosomal aberrations. Because FISH has a rapid turnaround
time, exceptional sensitivity, and can be performed on samples
with either metaphase (dividing) or interphase (non-dividing)
cells, as well as those with a low mitotic activity as in Chronic Lymphoma Leukemia (CLL),
it can be utilized as both confirmation for cytogenetic
findings and an independent diagnostic and prognostic tool.
Full color probe images are
provided with all Genoptix cytogenetics reports and results are
correlated with morphology, flow cytometry, cytogenetics and
PCR through COMPASS.
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